The Patient Centered Outcomes Research Institute is up and running!! So, what does PCORI mean for those of us interested in the science of Comparative Effectiveness Research and the intersection with Health Economics and Outcomes Research? First, lots of jargon here and some of it pretty turgid. CER has been discussed in our blog several times but in a nutshell---trying to figure out what really works in clinical medicine so we can improve care, lower costs, and reduce errors. PCORI will be handing out some new money to support CER. We hope the Jefferson School of Population Health will be the beneficiary of some of this new funding soon. We are also launching our unique, on line Masters Degree in Applied Health Economics and Outcomes Research in September 2011. In my many speaking engagements, esepcially those with the pharmaceutical and biotech industries, I have been emphasizing the following---do not shy away from CER, rather, embrace it!! The Accountable Care Organizations of the future will want products that work, and that are cost effective. ACOs, especially those that have risk, will want to make sure that they are practicing evidence based medicine and using products that are supported by that evidence. I know that these terms are confusing, but stay tuned in this space for more on PCORI, HEOR, CER, ACOs and all the rest. We will continue to try to clear the fog of jargon and help to make sense out of some very important new policies. DAVID NASH