spinach/berry smoothie
blueberry/cherry "compote"
New Year's eve
The Body Fat Setpoint
How is it that most peoples' body fat mass stays relatively stable over long periods of time, when an imbalance of as little as 5% of calories should lead to rapid changes in weight? Is it because we do complicated calculations in our heads every day, factoring in basal metabolic rate and exercise, to make sure our energy intake precisely matches expenditure? Of course not. We're gifted with a sophisticated system of hormones and brain regions that do the calculations for us unconsciously*.
When it's working properly, this system precisely matches energy intake to expenditure, ensuring a stable and healthy fat mass. It does this by controlling food seeking behaviors, feelings of fullness and even energy expenditure by heat production and physical movements. If you eat a little bit more than usual at a meal, a properly functioning system will say "let's eat a little bit less next time, and also burn some of it off." This is why animals in their natural habitat are nearly always at an appropriate weight, barring starvation. The only time wild animals are overweight enough to compromise maximum physical performance is when it serves an important purpose, such as preparing for hibernation.
I recently came across a classic study that illustrates these principles nicely in humans, titled "Metabolic Response to Experimental Overfeeding in Lean and Overweight Healthy Volunteers", by Dr. Erik O. Diaz and colleagues (1). They overfed lean and modestly overweight volunteers 50% more calories than they naturally consume, under controlled conditions where the investigators could be confident of food intake. Macronutrient composition was 12-42-46 % protein-fat-carbohydrate.
After 6 weeks of massive overfeeding, both lean and overweight subjects gained an average of 10 lb (4.6 kg) of fat mass and 6.6 lb (3 kg) of lean mass. Consistent with what one would expect if the body were trying to burn off excess calories and return to baseline fat mass, the metabolic rate and body heat production of the subjects increased.
Following overfeeding, subjects were allowed to eat however much they wanted for 6 weeks. Both lean and overweight volunteers promptly lost 6.2 of the 10 lb they had gained in fat mass (61% of fat gained), and 1.5 of the 6.6 lb they had gained in lean mass (23%). Here is a graph showing changes in fat mass for each individual that completed the study:
We don't know if they would have lost the remaining fat mass in the following weeks because they were only followed for 6 weeks after overfeeding, although it did appear that they were reaching a plateau slightly above their original body weight. Thus, nearly all subjects "defended" their original body fat mass irrespective of their starting point. Underfeeding studies have shown the same phenomenon: whether lean or overweight, people tend to return to their original fat mass after underfeeding is over. Again, this supports the idea that the body has a body fat mass "set point" that it attempts to defend against changes in either direction. It's one of many systems in the body that attempt to maintain homeostasis.
OK, so why do we care?
We care because this has some very important implications for human obesity. With such a powerful system in place to keep body fat mass in a narrow range, a major departure from that range implies that the system isn't functioning correctly. In other words, obesity has to result from a defect in the system that regulates body fat, because a properly functioning system would not have allowed that degree of fat gain in the first place.
So yes, we are gaining weight because we eat too many calories relative to energy expended. But why are we eating too many calories? Because the system that should be defending a low fat mass is now defending a high fat mass. Therefore, the solution is not simply to restrict calories, or burn more calories through exercise, but to try to "reset" the system that decides what fat mass to defend. Restricting calories isn't necessarily a good solution because the body will attempt to defend its setpoint, whether high or low, by increasing hunger and decreasing its metabolic rate. That's why low-calorie diets, and most diets in general, typically fail in the long term. It's miserable to fight hunger every day.
This raises two questions:
- What caused the system to defend a high fat mass?
- Is it possible to reset the fat mass setpoint, and how would one go about it?
* The hormone leptin and the hypothalamus are the ringleaders, although there are many other elements involved, such as numerous gut-derived peptides, insulin, and a number of other brain regions.
dec. 29 food
butternut squash/apple bake
Dec. 28 food
Review of Avatar
"Religion exists, in part, precisely because humans aren’t at home amid these cruel rhythms. We stand half inside the natural world and half outside it. We’re beasts with self-consciousness, predators with ethics, mortal creatures who yearn for immortality.It is interesting to hear such thoughts expressed in the NYT. Maybe I'm not as critical a thinker as I need to be, or I'm secure in my world view, but this neither bothered me, nor seduced me while I was watching it. I actually found the movie quite amazing and well-worth the watching in the theater.
This is an agonized position, and if there’s no escape upward — or no God to take on flesh and come among us, as the Christmas story has it — a deeply tragic one.
Pantheism offers a different sort of solution: a downward exit, an abandonment of our tragic self-consciousness, a re-merger with the natural world our ancestors half-escaped millennia ago.
But except as dust and ashes, Nature cannot take us back."
I have read this critical review knocking the movie as an "anti-war politic[al] movie". But after watching the film, I walked away thinking I agreed with the movie's "agenda" as I understand it. It really was more of an anti-colonialism movie, which I can proudly say America does NOT embrace this ideology. Yes, we have a history of it, but not anymore. And as we look back and see the destruction that colonialism had on a native people, this movie portrays that well. No one group of people has the right to enslave or exile another group for the first group's own benefit - no matter how you slice it. That was the political message I got. Additionally, the "anti-war" agenda that was present was more tied to this use of the military, more than a pure "anti-war" theme. Of course, there were the stereo-typical strawmen comments/arguments in the movie. But overall, they are easily over-looked for the benefit of the rest of the movie.
As I saw it, it was a brilliant and redeeming portrayal of an ugly historical theme. World history has reflected the battle of colonialism countless times. The movie portrayed it in a future setting in another world. Aside from that, it was fascinating, creative, beautiful, and moving, as well as scientifically curious related to the "avatar" technology. I overlooked the pantheism the movie presented - it actually reminded me of a Native American culture, which was not offensive to me. I highly recommend this movie. It's great eye candy.
Fun weekend cooking!
kale fennel soup
Banana oatmeal cookies
cashew cookies
Great new blog
holiday eating
I had an enjoyable holiday season. However, I did go off the healthy eating plan on 3 occasions over the course of 2 days, at a party and at two restaurant meals. I rationalized it as follows: I’m thin and healthy (knock on wood) and Dr. Fuhrman says 90% compliance is enough to maintain health. So I’m well within his parameters. But I have to say, I don’t think it’s worth it! The effect of unhealthy food on a healthy body is too much of a shock. I felt hungover for 3 days after this, and what fun is that? And I didn’t even eat that unhealthy, compared to normal standards. At the party I had small servings of lentil salad, chick pea salad, hummus, tempeh, chocolate pudding (made with tofu), chips & salsa, and a few vegan cookies. I have to admit I enjoyed the salt a lot. But I hardly slept that night from the sugar and chocolate. At one of the restaurant meals I had a tofu scramble burrito, fried potatoes, toast with earth balance (margarine), and a decaff soy latte. At the other restaurant meal, I had hummus & pita bread, a couple of small falafels (deep fried!), and baklava (very sweet! and, yes, good). It all tasted good, but mainly due to the salt—try eating that stuff without salt and it’s bland, I guarantee. Again, I was surprised by my attraction to the salt. But then I paid for it. My hands got uncomfortably swollen, and my nose bled a little. I suspect this is harmful to the body to go from no salt to a ton of salt in one day. And the same goes for a body not used to sugar, caffeine, and chocolate. I’m glad I didn’t try the alcohol.
Tomorrow I will have to go grocery shopping, though it would be fun to see how far I can go with what I have in the fridge. It’s now mostly carrots and some cabbage and oranges, and one cup of beans. Hmmm. Well, that combo would probably taste good too!
Blog update
I took a little break from blogging over the holidays. I'm hoping to start up a new hobby soon, so I think I will have to cut back on blogging to fit it in. I’ll probably cut back on the daily food logs and just post recipes or rants. I did the daily food logs to provide examples for how to eat healthy on a daily basis (when I do it right!). There are plenty of old posts if someone wants to see that still. Just click on the “food logs” label at right to see hundreds of posts.
Rabbits on a High-Saturated Fat Diet Without Added Cholesterol
In this study, they fed four groups of rabbits different diets:
- Regular low-fat rabbit chow
- Regular low-fat rabbit chow plus 0.5 g cholesterol per day
- High-fat diet with 30% calories as coconut oil (saturated) and no added cholesterol
- High-fat diet with 30% calories as sunflower oil (polyunsaturated) and no added cholesterol
Total cholesterol was also the same between all groups except the cholesterol-fed group. TBARS, a measure of lipid oxidation in the blood, was elevated in the cholesterol and sunflower oil groups but not in the chow or coconut groups. Oxidation of blood lipids is one of the major factors in atherosclerosis, the vascular disease that narrows arteries and increases the risk of having a heart attack. Serum vitamin C was lower in the cholesterol-fed groups but not the others.
This supports the idea that saturated fat does not inherently increase LDL, and in fact in most animals it does not. This appears to be the case in humans as well, where long-term trials have shown no difference in LDL between people eating more saturated fat and people eating less, on timescales of one year or more (some short trials show a modest LDL-raising effect, but even this appears to be due to an increase in particle size rather than particle number). Since these trials represent the average of many people, they may hide some individual variability: it may actually increase LDL in some people and decrease it in others.
Merry Christmas!
My New House So Far - UPDATED
I bought a house this year taking advantage of the fed grant for first-time home-buyers. Here are some before/during pictures (I'm not to the "After" stage yet).
When you walk into the house you used to see into a hallway staring at the furnace closet. Now you see an entryway closet and there is just a foyer, no hallway anymore.
This is looking toward the kitchen at a door that goes to the car port and another (on the left) that goes to the laundry room. The wall on the right is where the double oven is. I tore out all the panelling, took out that full wall and moved it out another foot or so, creating a breakfast bar and expanding the kitchen to include the eating area on the left of the first picture. (I closed off the door on the right to the car part)
[Here is the same view -one before and one now with paint and cabinets]
Here is a view looking from other corner into the same room. I closed of the door going into the back yard on the far right and took out the window to make room for the wall going across the room and added the french doors.
[Here's what it looks like now with paint and cabinets and furniture]
Here's what it looked like from inside and outside the house to close off the door and window and make an opening for the French doors.
This is the living room looking at the wall to the dining room/kitchen. The door on the right goes down the hallway to the bedrooms. So to create more of a Great Room/open floor plan, I have cut 2 six-foot doorways into the dining room and taken out the door to the hallway. Right now the new cabinets are sitting in the living room waiting for the kitchen to be done.
Well, I'm getting close to finishing the new drywall in the kitchen and dining room and then will be able to paint. It will be nice to have things put in place soon. Stay tuned for the "after" pictures. And feel free to come visit!
Global Warming Takes on the Family Pet
Combine the land required to generate its food and a "medium" sized dog has an annual footprint of 0.84 hectares (2.07 acres) -- around twice the 0.41 hectares required by a 4x4 driving 10,000 kilometres (6,200 miles) a year, including energy to build the car....But there was one point I could agree with in the article:
"Owning a dog really is quite an extravagance, mainly because of the carbon footprint of meat," Barrett said.
Other animals aren't much better for the environment, the Vales say.
Cats have an eco-footprint of about 0.15 hectares, slightly less than driving a Volkswagen Golf for a year, while two hamsters equates to a plasma television and even the humble goldfish burns energy equivalent to two mobile telephones....
And pets' environmental impact is not limited to their carbon footprint, as cats and dogs devastate wildlife, spread disease and pollute waterways, the Vales say.
But the best way of compensating for that paw or clawprint is to make sure your animal is dual purpose, the Vales urge. Get a hen, which offsets its impact by laying edible eggs, or a rabbit, prepared to make the ultimate environmental sacrifice by ending up on the dinner table.I've always said, "I like cats - they taste like chicken."
"Rabbits are good, provided you eat them," said Robert Vale.
What's the Ideal Fasting Insulin Level?
Elevated fasting insulin is a hallmark of the metabolic syndrome, the quintessential modern metabolic disorder that affects 24% of Americans (NHANES III). Dr. Lamarche and colleagues found that having an insulin level of 13 uIU/mL in Canada correlated with an 8-fold higher heart attack risk than a level of 9.3 uIU/mL (1; thanks to NephroPal for the reference). So right away, we can put our upper limit at 9.3 uIU/mL. The average insulin level in the U.S., according to the NHANES III survey, is 8.8 uIU/mL for men and 8.4 for women (2). Given the degree of metabolic dysfunction in this country, I think it's safe to say that the ideal level of fasting insulin is probably below 8.4 uIU/mL as well.
Let's dig deeper. What we really need is a healthy, non-industrial "negative control" group. Fortunately, Dr. Staffan Lindeberg and his team made detailed measurements of fasting insulin while they were visiting the isolated Melanesian island of Kitava (3). He compared his measurements to age-matched Swedish volunteers. In male and female Swedes, the average fasting insulin ranges from 4-11 uIU/mL, and increases with age. From age 60-74, the average insulin level is 7.3 uIU/mL.
In contrast, the range on Kitava is 3-6 uIU/mL, which does not increase with age. In the 60-74 age group, in both men and women, the average fasting insulin on Kitava is 3.5 uIU/mL. That's less than half the average level in Sweden and the U.S. Keep in mind that the Kitavans are lean and have an undetectable rate of heart attack and stroke.
Another example from the literature are the Shuar hunter-gatherers of the Amazon rainforest. Women in this group have an average fasting insulin concentration of 5.1 uIU/mL (4; no data was given for men).
I found a couple of studies from the early 1970s as well, indicating that African pygmies and San bushmen have rather high fasting insulin. Glucose tolerance was excellent in the pygmies and poor in the bushmen (5, 6, free full text). This may reflect differences in carbohydrate intake. San bushmen consume very little carbohydrate during certain seasons, and thus would likely have glucose intolerance during that period. There are three facts that make me doubt the insulin measurements in these older studies:
- It's hard to be sure that they didn't eat anything prior to the blood draw.
- From what I understand, insulin assays were variable and not standardized back then.
- In the San study, their fasting insulin was 1/3 lower than the Caucasian control group (10 vs. 15 uIU/mL). I doubt these active Caucasian researchers really had an average fasting insulin level of 15 uIU/mL. Both sets of measurements are probably too high.
We also have data from a controlled trial in healthy urban people eating a "paleolithic"-type diet. On a paleolithic diet designed to maintain body weight (calorie intake had to be increased substantially to prevent fat loss during the diet), fasting insulin dropped from an average of 7.2 to 2.9 uIU/mL in just 10 days. The variation in insulin level between individuals decreased 9-fold, and by the end, all participants were close to the average value of 2.9 uIU/mL. This shows that high fasting insulin is correctable in people who haven't yet been permanently damaged by the industrial diet and lifestyle. The study included men and women of European, African and Asian descent (7).
One final data point. My own fasting insulin, earlier this year, was 2.3 uIU/mL. I believe it reflects a good diet, regular exercise, sufficient sleep, a relatively healthy diet growing up, and the fact that I managed to come across the right information relatively young. It does not reflect: carbohydrate restriction, fat restriction, or saturated fat restriction. Neither does the low fasting insulin of healthy non-industrial cultures.
So what's the ideal fasting insulin level? My current feeling is that we can consider anything between 2 and 6 uIU/mL within our evolutionary template, although the lower half of that range may be preferable.
Guest Commentary: Where are Nurse Practitioners in Health Care Reform?
Coordinator, Advanced Practice Oncology Nursing Program
Assistant Professor, Jefferson Schools of Nursing and Population Health
(Former President of the Nurse Practitioner Association of Maryland)
Cortese and Korsmo, in their September 23, 2009 article in the NEJM, observed that, “Americans do not consistently receive high-value health care. Collectively, our country spends more on health care than any other nation, but our people do not receive the best outcomes, safety, service, or access (to health care) in return.”
Our health care system is largely dominated by a plethora of specialists but deficient in primary care physicians. At a time when only 247 residency positions in primary care are available for graduating medical students per year (down 328 residency positions since 1999), over 6,000 nurse practitioners (NPs) are educated each year at more than 325 colleges and universities. Most of these NPs choose primary care or family practice settings for employment. (For the uninitiated, NPs are fully-trained and licensed registered nurses who complete a Master’s or doctoral degree as an advanced practice nurse and pass a certifying examination administered by a national board, which allows them to be licensed by state boards of nursing as a NP).
NP educational programs provide training in the diagnosis and treatment of acute minor illnesses, disease prevention, and management of stable chronic conditions. Nurse practitioners are part of the solution in health care reform and fill an important niche in providing access to a qualified health care provider for millions of Americans. NPs are a win-win for patients – NPs bring their education, compassion and experience as RNs to bear on patient care, yet they are paid less than physicians. An ever growing body of evidence points to comparable quality care – and often higher patient satisfaction – with NPs as primary health care providers. Currently there are 139,000 NPs practicing in the US.
So why is the AMA threatened by NPs? In October 2009 the AMA launched an offensive, targeting NP practice in a document entitled: AMA Scope of Practice Data Series – Nurse practitioners. The document states in part that: “The physician is responsible for the supervision of nurse practitioners and other advanced practice nurses in all settings and that the physician is responsible for managing the health care of patients in all practice settings.” This is blatantly untrue. Nursing has been a self-regulating and self-licensing profession for as long as medicine has. Why has the leadership of the AMA decided that physicians and only physicians have the “right” to assess, diagnose and treat ill persons and that all “non-physician providers” should be supervised by a physician?
The American Nurses’ Association recently issued a response to this AMA document, voicing its objection to the AMA’s attempts to change the public’s perception of NP practice as anything other than fully qualified professionals working within a legally established scope of practice. As America struggles to reconstruct its health care delivery “system,” it is unproductive for one profession to attempt to marginalize another. NPs stand ready to help meet the nation’s health care needs as collaborating partners, not as physician supervised providers. Health care reformers look our way!
dec. 20 food
O Holy Night
smoothie time
last few days
Don't Waste Your Cancer - John Piper
1. You will waste your cancer if you do not believe it is designed for you by God.
2. You will waste your cancer if you believe it is a curse and not a gift.
3. You will waste your cancer if you seek comfort from your odds rather than from God.
4. You will waste your cancer if you refuse to think about death.
5. You will waste your cancer if you think that “beating” cancer means staying alive rather than cherishing Christ.
6. You will waste your cancer if you spend too much time reading about cancer and not enough time reading about God.
7. You will waste your cancer if you let it drive you into solitude instead of deepen your relationships with manifest affection.
8. You will waste your cancer if you grieve as those who have no hope.
9. You will waste your cancer if you treat sin as casually as before.
10. You will waste your cancer if you fail to use it as a means of witness to the truth and glory of Christ.
Quote of the Week
This week has been truly historic. It has marked the beginning of the landslide that is collapsing the whole AGW imposture. The pseudo-science of global warming is a global laughing stock and Copenhagen is a farce. In the warmist camp the Main Man is a railway engineer with huge investments in the carbon industry. That says it all. The world’s boiler being heroically damped down by the Fat Controller. Al Gore, occupant of the only private house that can be seen from space, so huge is its energy consumption, wanted to charge punters $1,200 to be photographed with him at Copenhagen. There is a man who is really worried about the planet’s future.
What Causes Terrorism?
After 17 years of attacks, we should have learned the difference between causes of terrorism and pretexts for terrorism. Terrorism is caused, and terrorist recruitment is driven, by Islamist ideology and by American weakness in the face of terror attacks. In that sense, Senator Durbin causes more terrorism than Gitmo ever will. Terrorist organizations are encouraged when they come to believe they can win — when they come to believe they can outlast America because we lack resolve.
Sarah Palin is Straight?
"The failed Vice Presidential nominee took time off from shilling her book to vacation with her son Trig, daughter Piper and opposite sex spouse Todd, in President Barack Obama's birth state of Hawaii on Tuesday."I guess I just always thought that would be assumed unless otherwise noted!
Climategate Spreading
The IEA believes that Russian meteorological-station data did not substantiate the anthropogenic global-warming theory. Analysts say Russian meteorological stations cover most of the country’s territory, and that the Hadley Center had used data submitted by only 25% of such stations in its reports. Over 40% of Russian territory was not included in global-temperature calculations for some other reasons, rather than the lack of meteorological stations and observations.And it seems like this issue has been around for some time based on the following source:
The data of stations located in areas not listed in the Hadley Climate Research Unit Temperature UK (HadCRUT) survey often does not show any substantial warming in the late 20th century and the early 21st century.
The HadCRUT database includes specific stations providing incomplete data and highlighting the global-warming process, rather than stations facilitating uninterrupted observations.
On the whole, climatologists use the incomplete findings of meteorological stations far more often than those providing complete observations.
IEA analysts say climatologists use the data of stations located in large populated centers that are influenced by the urban-warming effect more frequently than the correct data of remote stations.
The scale of global warming was exaggerated due to temperature distortions for Russia accounting for 12.5% of the world’s land mass. The IEA said it was necessary to recalculate all global-temperature data in order to assess the scale of such exaggeration.
Global-temperature data will have to be modified if similar climate-date procedures have been used from other national data because the calculations used by COP15 analysts, including financial calculations, are based on HadCRUT research.
As Steve McIntyre reports at ClimateAudit, it has long been suspected that the CRU had been playing especially fast and loose with Russian – more particularly Siberian – temperature records. Here from March 2004, is an email from Phil Jones to Michael Mann.And then there's this video posted at Hot Air reviewing the computer model programming from CRU:Recently rejected two papers (one for JGR and for GRL) from people saying CRU has it wrong over Siberia. Went to town in both reviews, hopefully successfully. If either appears I will be very surprised, but you never know with GRL.
Cheers
Phil
Dec. 15 food
What was I thinking?
The Dirty Little Secret of the Diet-Heart Hypothesis
The fact is, the vast majority of high-quality observational studies have found no connection whatsoever between saturated fat consumption and heart attack risk. The scientific literature contains dozens of these studies, so let's narrow the field to prospective studies only, because they are considered the most reliable. In this study design, investigators find a group of initially healthy people, record information about them (in this case what they eat), and watch who gets sick over the years.
A Sampling of Unsupportive Studies
Here are references to ten high-impact prospective studies, spanning half a century, showing no association between saturated fat consumption and heart attack risk. Ignore the squirming about saturated-to-polyunsaturated ratios, Keys/Hegsted scores, etc. What we're concerned with is the straightforward question: do people who eat more saturated fat have more heart attacks? Many of these papers allow free access to the full text, so have a look for yourselves if you want:
A Longitudinal Study of Coronary Heart Disease. Circulation. 1963.
Diet and Heart: a Postscript. British Medical Journal. 1977. Saturated fat was unrelated to heart attack risk, but fiber was protective.
Dietary Intake and the Risk of Coronary Heart Disease in Japanese Men Living in Hawaii. American Journal of Clinical Nutrition. 1978.
Relationship of Dietary Intake to Subsequent Coronary Heart Disease Incidence: the Puerto Rico Heart Health Program. American Journal of Clinical Nutrition. 1980.
Diet, Serum Cholesterol, and Death From Coronary Heart Disease: The Western Electric Study. New England Journal of Medicine. 1981.
Diet and 20-year Mortality in Two Rural Population Groups of Middle-Aged Men in Italy. American Journal of Clinical Nutrition. 1989. Men who died of CHD ate significantly less saturated fat than men who didn't.
Diet and Incident Ischaemic Heart Disease: the Caerphilly Study. British Journal of Nutrition. 1993. They measured animal fat intake rather than saturated fat in this study.
Dietary Fat and Risk of Coronary Heart Disease in Men: Cohort Follow-up Study in the United States. British Medical Journal. 1996. This is the massive Physicians Health Study. Don't let the abstract fool you! Scroll down to table 2 and see for yourself that the association between saturated fat intake and heart attack risk disappears after adjustment for several factors including family history of heart attack, smoking and fiber intake. That's because, as in most modern studies, people who eat steak are also more likely to smoke, avoid vegetables, eat fast food, etc.
Dietary Fat Intake and the Risk of Coronary Heart Disease in Women. New England Journal of Medicine. 1997. From the massive Nurse's Health study. This one fooled me for a long time because the abstract is misleading. It claims that saturated fat was associated with heart attack risk. However, the association disappeared without a trace when they adjusted for monounsaturated and polyunsaturated fat intake. Have a look at table 3.
Dietary Fat Intake and Early Mortality Patterns-- Data from the Malmo Diet and Cancer Study. Journal of Internal Medicine. 2005.
I just listed 10 prospective studies published in top peer-reviewed journals that found no association between saturated fat and heart disease risk. This is less than half of the prospective studies that have come to the same conclusion, representing by far the majority of studies to date. If saturated fat is anywhere near as harmful as we're told, why are its effects essentially undetectable in the best studies we can muster?
Studies that Support the Diet-Heart Hypothesis
To be fair, there have been a few that have found an association between saturated fat consumption and heart attack risk. Here's a list of all four that I'm aware of, with comments:
Ten-year Incidence of Coronary Heart Disease in the Honolulu Heart Program: relationship to nutrient intake. American Journal of Epidemiology. 1984. "Men who developed coronary heart disease also had a higher mean intake of percentage of calories from protein, fat, saturated fatty acids, and polyunsaturated fatty acids than men who remained free of coronary heart disease." The difference in saturated fat intake between people who had heart attacks and those who didn't, although statistically significant, was minuscule.
Diet and 20-Year Mortality From Coronary Heart Disease: the Ireland-Boston Diet-Heart Study. New England Journal of Medicine. 1985. "Overall, these results tend to support the hypothesis that diet is related, albeit weakly, to the development of coronary heart disease."
Relationship Between Dietary Intake and Coronary Heart Disease Mortality: Lipid Research Clinics Prevalence Follow-up Study. Journal of Clinical Epidemiology. 1996. "...increasing percentages of energy intake as total fat (RR 1.04, 95% CI = 1.01 – 1.08), saturated fat (RR 1.11, CI = 1.04 – 1.18), and monounsaturated fat (RR 1.08, CI = 1.01 – 1.16) were significant risk factors for CHD mortality among 30 to 59 year olds... None of the dietary components were significantly associated with CHD mortality among those aged 60–79 years." Note that the associations were very small, also included monounsaturated fat (like in olive oil), and only applied to the age group with the lower risk of heart attack.
The Combination of High Fruit and Vegetable and Low Saturated Fat Intakes is More Protective Against Mortality in Aging Men than is Either Alone. Journal of Nutrition. 2005. Higher saturated fat intake was associated with a higher risk of heart attack; fiber was strongly protective.
The Review Papers
Over 25 high-quality studies conducted, and only 4 support the diet-heart hypothesis. If this substance is truly so fearsome, why don't people who eat more of it have more heart attacks? In case you're concerned that I'm cherry-picking studies that conform to my beliefs, here are links to review papers on the same data that have reached the same conclusion:
The Questionable Role of Saturated and Polyunsaturated Fatty Acids in Cardiovascular Disease. Journal of Clinical Epidemiology. 1998. Dr. Uffe Ravnskov systematically demolishes the diet-heart hypothesis simply by collecting all the relevant studies and summarizing their findings.
A Systematic Review of the Evidence Supporting a Causal Link Between Dietary Factors and Coronary Heart Disease. Archives of Internal Medicine. 2009. "Insufficient evidence (less than or equal to 2 criteria) of association is present for intake of supplementary vitamin E and ascorbic acid (vitamin C); saturated and polyunsaturated fatty acids; total fat; alpha-linolenic acid; meat; eggs; and milk" They analyzed prospective studies representing over 160,000 patients from 11 studies meeting their rigorous inclusion criteria, and found no association whatsoever between saturated fat consumption and heart attack risk.
Where's the Disconnect?
The first part of the diet-heart hypothesis states that dietary saturated fat raises the cholesterol/LDL concentration of the blood. This is held as established fact in the mainstream understanding of nutrition. The second part states that increased blood cholesterol/LDL increases the risk of having a heart attack. What part of this is incorrect?
There's definitely an association between blood cholesterol/LDL level and heart attack risk in certain populations, including Americans. MRFIT, among other studies, showed this definitively, although the lowest risk of all-cause mortality was at an average level of cholesterol. The association between blood cholesterol and heart attack risk does not apply to Japanese populations, as pointed out repeatedly by Dr. Harumi Okuyama. This seems to be generally true of groups that consume a lot of seafood.
So we're left with the first premise: that saturated fat increases blood cholesterol/LDL. This turns out to be largely a short-term effect. In fact, it isn't even true in animal models of heart disease if you exclude those that use large doses of dietary cholesterol. In the 1950s, the most vigorous proponent of the diet-heart hypothesis, Dr. Ancel Keys, created a formula designed to predict changes in blood cholesterol based on the consumption of dietary saturated and polyunsaturated fats. This formula does not have a very good predictive value in long-term controlled trials and its use in the modern medical literature is declining.
This is it, folks: the diet-heart hypothesis ends here. It's been kept afloat for decades by wishful thinking and selective citation of the evidence. It's time to put it out of its misery.
Blog Archive
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- spinach/berry smoothie
- blueberry/cherry "compote"
- New Year's eve
- The Body Fat Setpoint
- dec. 29 food
- butternut squash/apple bake
- Dec. 28 food
- Review of Avatar
- Fun weekend cooking!
- kale fennel soup
- Banana oatmeal cookies
- cashew cookies
- Great new blog
- holiday eating
- Blog update
- Rabbits on a High-Saturated Fat Diet Without Added...
- My New House So Far - UPDATED
- Global Warming Takes on the Family Pet
- What's the Ideal Fasting Insulin Level?
- Guest Commentary: Where are Nurse Practitioners in...
- dec. 20 food
- O Holy Night
- smoothie time
- last few days
- Don't Waste Your Cancer - John Piper
- A Look at Charity
- Quote of the Week
- What Causes Terrorism?
- Sarah Palin is Straight?
- Climategate Spreading
- Dec. 15 food
- What was I thinking?
- The Dirty Little Secret of the Diet-Heart Hypothesis
- Harmonica Like You've Never Heard
- dec 14 food
- A Fake Christmas Tree
- City Police Put the Squeeze on Lemonade Stand
- Dec. 13 food
- Eating Animals
- Dr. Fuhrman's Eating Plan
- butternut squash
- dec. 12 food
- dec. 11 food
- Guest Commentary: Healthcare Reform is Fiscal Reform
- dec. 10 food
- beans & veggies & seeds
- peanut/banana spread and boiled peanuts
- JSPH is Making Lemonade
- Climategate "Smoking Gun"?
- dec. 9
- JSPH Health Policy Forum: Cultural Competency
- dec. 8
- Guest Commentary: President Obama visits Pennsylvania
- Butyric Acid: an Ancient Controller of Metabolism,...
- dec. 7 food
- dec. 6 food
- dec. 5 food
- dec. 4 food
- Welcome to Hattiesburg
- Fireflies
- Climate Gate
- Dec. 3 food
- Malocclusion: Disease of Civilization, Part IX
- Dec. 2 food
- cabbage/greens salad
- back in town
- New housemate's smoothie
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December
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