Acne: Disease of Civilization
I recently read an interesting paper written by an all-star cast, including Loren Cordain, Staffan Lindeberg and Boyd Eaton. It's titled "Acne Vulgaris: A Disease of Western Civilization". The paper presents data from two different groups, the Kitavans of Papua New Guinea and the Ache hunter-gatherers of Paraguay. Both were systematically examined by doctors trained to diagnose acne. Out of 1,200 Kitavans and 115 Ache of all ages, not a single case of acne was observed. Hunter-gatherers and other healthy non-industrial cultures have nice skin. I dare you to find a pimple in Nutrition and Physical Degeneration.
In Western societies, acne is a fact of life. The paper states that 79 to 95% of modern adolescents suffer from some degree of acne, along with about 50% of young adults. That's an enormous difference.
The paper presents a very Cordain-esque hypothesis to explain the high incidence of acne in Western societies. In sum, they state that the Western diet causes hyperinsulinemia, which is thought to promote acne. This is due to insulin's effects on skin cell proliferation, its interference with the retinoid (vitamin A) signaling pathway, and its effect on sebum production.
They then proceed to point the finger at the glycemic index/load of the Western diet as the culprit behind hyperinsulinemia. It's an unsatisfying explanation because the Kitavans eat a diet that has a high glycemic load due to its high carbohydrate content, low fat content, and relatively high-glycemic index foods. I think the answer is more likely to reside in the specific types of carbohydrate (processed wheat) rather than their speed of digestion, with possible contributions from refined vegetable oil and an excessive sugar intake.
nachos
Collard green smoothie
1-2 Tbsp sunflower or pumpkin seeds (optional)
sept. 28-29 food
The Meaning of Mission
Ratatouille
sept. 27 food
sept. 26 food
Nonalcoholic Fatty Liver Disease
There are certain animal models of human disease that are so informative I keep coming back to them again and again. One of my favorites is the LIRKO mouse, or liver-specific insulin receptor knockout mouse. The LIRKO mouse is missing its insulin receptor in the liver only, so it is a model of severe insulin resistance of the liver. It accumulates a small amount of fat in its liver in old age, but nothing that resembles NAFLD. So liver insulin resistance doesn't lead to NAFLD or NASH, at least in this model.
What else happens to the LIRKO mouse? It develops severe whole-body insulin resistance, impaired glucose tolerance, high fasting blood glucose and hyperinsulinemia (chronically elevated insulin). So insulin resistance in the liver is sufficient to cause whole-body insulin resistance, hyperinsulinemia and certain other hallmarks of the metabolic syndrome, while liver and whole-body insulin resistance are not sufficient to cause NAFLD or NASH. This is consistent with the fact that nearly everyone with NAFLD is insulin resistant, while many who are insulin resistant do not have NAFLD.
In all fairness, there are reasons why NAFLD is believed to be caused by insulin resistance. For example, insulin-sensitizing drugs improve NAFLD. However, that doesn't mean the initial metabolic 'hit' wasn't in the liver. One could imagine a scenario in which liver insulin resistance leads to insulin resistance in other tissues, which creates a positive feedback that aggravates NAFLD. Or perhaps NAFLD requires two 'hits', one to peripheral insulin sensitivity and another directly to the liver.
In any case, I feel that the most plausible mechanism for NAFLD goes something like this: too much n-6 from polyunsaturated vegetable oil (along with insufficient n-3), plus too much fructose from sweeteners, combine to cause NAFLD. The liver becomes insulin resistant at this point, leading to whole-body insulin resistance, hyperinsulinemia, impaired glucose tolerance and general metabolic havoc.
sept 25, 2008 food
daal with quinoa and peas
blueberry fig sorbet
what this blog is about
sept 23-24 food
Agave Syrup
Agave syrup is made from the heart of the agave plant, which is pressed to release a juice rich in inulin. Inulin is a polymer made of fructose molecules. The inulin is then broken down either by heat or by enzymatic processing. The result is a sweet syrup that is rich in fructose.
Agave syrup is marketed as a healthy, alternative sweetener. In fact, it's probably as bad or worse than high-fructose corn syrup (HFCS). They are both a refined and processed plant extract. Both are high in fructose, with agave syrup leading HFCS (estimates of agave syrup range up to 92% fructose by calories). Finally, agave syrup is expensive and inefficient to produce.
The high fructose content gives agave syrup a low glycemic index, because fructose does not raise blood glucose. Unfortunately, as some diabetics learned the hard way, using fructose as a substitute for sucrose (cane sugar) has negative long-term effects on insulin sensitivity.
In my opinion, sweeteners come with risks and there is no free lunch. The only solution is moderation.
How to Fatten Your Liver
This week, I've been reading about how to fatten your liver. First up: industrial vegetable oil. The study that initially sent me on this nerd safari was recently published in the Journal of Nutrition. It's titled "Increased Apoptosis in High-Fat Diet–Induced Nonalcoholic Steatohepatitis in Rats Is Associated with c-Jun NH2-Terminal Kinase Activation and Elevated Proapoptotic Bax". Quite a mouthful. The important thing for the purpose of this post is that the investigators fed rats a high-fat diet, which induced NASH.
Anytime a study mentions a "high-fat diet", I immediately look to see what they were actually feeding the animals. To my utter amazement, there was no information on the composition of the high-fat diet in the methods section, only a reference to another paper. Apparently fat composition is irrelevant. Despite the fact that a high-fat diet from coconut oil or butter does not produce NASH in rats. Fortunately, I was able to track down the reference. The only difference between the standard diet and the high-fat diet was the addition of a large amount of corn oil and the subtraction of carbohydrate (dextrin maltose).
Corn oil is one of the worst vegetable oils. You've eaten corn so you know it's not an oily seed. To concentrate the oil and make it palatable, manufacturers use organic solvents, high heat, and several rounds of chemical treatment. It's also extremely rich in n-6 linoleic acid. The consumption of corn oil and other n-6 rich oils has risen dramatically in the US in the last 30 years, making them prime suspects in NASH. They have replaced the natural (more saturated) fats we once got from meat and milk.
Next up: fructose. Feeding rats an extreme amount of fructose (60% of calories) gives them nonalcoholic fatty liver disease (NAFLD), NASH's younger sibling, even when the fat in their chow is lard. Given the upward trend of US fructose consumption (mostly from high-fructose corn syrup), and the refined sugar consumed everywhere else (50% fructose), it's also high on my list of suspects.
Here's my prescription for homemade foie gras: take one serving of soybean oil fried french fries, a basket of corn oil fried chicken nuggets, a healthy salad drenched in cottonseed oil ranch dressing, and wash it all down with a tall cup of soda. It's worked for millions of Americans!
"Spaghetti"
food sept 21-22
food Sept. 20, 08
back from my trip
A New Toy
"Glucose intolerance" is the inability to effectively control blood glucose as it enters the bloodstream from the digestive system. It results in elevated blood sugar after eating carbohydrate, which is not a good thing. In someone with normal glucose tolerance, insulin is secreted in sufficient amounts, and the tissues are sufficiently sensitive to it, that blood glucose is kept within a fairly tight range of concentrations.
Glucose tolerance is typically the first thing to deteriorate in the process leading to type II diabetes. By the time fasting glucose is elevated, glucose intolerance is usually well established. Jenny Ruhl talks about this in her wonderful book Blood Sugar 101. Unfortunately, fasting glucose is the most commonly administered glucose test. That's because the more telling one, the oral glucose tolerance test (OGTT), is more involved and more expensive.
An OGTT involves drinking a concentrated solution of glucose and monitoring blood glucose at one and two hours. Values of >140 mg/dL at one hour and >120 mg/dL at two hours are considered "normal". If you have access to a blood glucose meter, you can give yourself a makeshift OGTT. You eat 60-70 grams of quickly-digesting carbohydrate with no fat to slow down absorption and monitor your glucose.
I gave myself an OGTT tonight. I ate a medium-sized boiled potato and a large slice of white bread, totaling about 60g of carbohydrate. Potatoes and bread digest very quickly, resulting in a blood glucose spike similar to drinking concentrated glucose! You can see that in the graph below. I ate at time zero. By 15 minutes, my blood glucose had reached its peak at 106 mg/dL.
My numbers were 97 mg/dL at one hour, and 80 mg/dL at two hours; far below the cutoff for impaired glucose tolerance. I completely cleared the glucose by an hour and 45 minutes. My maximum value was 106 mg/dL, also quite good. That's despite the fact that I used more carbohydrate for the OGTT than I would typically eat in a sitting. I hope you like the graph; I had to prick my fingers 10 times to make it! I thought it would look good with a lot of data points.
I'm going to have fun with this glucose meter. I've already gotten some valuable information. For example, just as I suspected, fast-digesting carbohydrate is not a problem for someone with a well-functioning pancreas and insulin-sensitive tissues. This is consistent with what we see in the Kitavans, who eat a high-carbohydrate, high glycemic load diet, yet are extremely healthy. Of course, for someone with impaired glucose tolerance (very common in industrial societies), fast-digesting carbohydrates could be the kiss of death. The big question is, what causes the pancreas to deteriorate and the tissues to become insulin resistant? Considering certain non-industrial societies were eating plenty of carbohydrate with no problems, it must be something about the modern lifestyle: industrially processed grains (particularly wheat), industrial vegetable oils, refined sugar, lack of fat-soluble vitamins, toxic pollutants and inactivity come to mind. One could make a case for any of those factors contributing to the problem.
The Assemblies of God
10 Rules of Political Bluffing
The Ten Rules
What are the Ten Rules to the Academic Bluff for Politicians (which will not set off pundit alarms about your smarts):
1. Never answer a question directly if you can avoid it.
2. Always rephrase or repeat the question using the terms found in the question at the start of your response.
3. As you are setting up your soon to come answer, use words like “subtle” and “complex” to describe the problem.
4. Compare your coming “subtle” answer with the “unsubtle” view of your foe.
5. At this point, you might be able to work in regret that you have run out of time and can stop. Do this as soon as you can. If you have a compliant interviewer, you can set up the question for a long time and then stop. You have survived the question without saying a thing! You will be given points for how your complexity cannot be fit in a brief video clip. You are now officially “deep.” You will make the interviewer feel cheap and shallow and lucky to have been able to partake in a moment of your constant First-Mover-like internal monologue.
6. Learn academic noises (”hmm. . . .”) that take a great deal of time off the clock while giving the appearance of thinking. (Don’t make the McCain “mistake” at Saddleback of actually answering questions . . . this goes quickly and leaves your interviewer time to ask more potential stumpers.)
7. Cite books and smart people you have read or consulted, but do NOT mention who they are. Have one all purpose book or person to use as an example . . . and when pressed to give an example, keep talking about that book or example until you run out of time.
8. Work in other issues (pollution in China) and connect them. If you have kept your earlier framing of the issue vague enough, you can make a quick connection that actually changes the subject. If pressed on global security, on which you might know less than you fear people want you to know (often unreasonably), this is a great strategy. You can say, “Pollution impacts us all. It is a global security problem.” Actually, it isn’t really (in the context security does not mean that), but it will get you points as a person who can connect Big Ideas on the fly!
9. If you are going to use no facts in your answer, use the word “facts.” Talking about facts is a great way to avoid mentioning any.
10. Leave your audience with the sense that you are “still in process.” Keep clarifying the question and expanding its scope until you run out of time. (Look at the quote above and tell me what the Obama doctrine actually is.) You will sound as if you had so much more wisdom to share, but the demands of commercials (darn it!) cut you off.
Joe Biden is a master of this if you are looking for another good teacher, but he is not Senator Obama’s equal since he often says bizarre things while filibustering.
Theology in Real Life
"Amen to this quote from Donald Macleod's The Humiliated and Exalted Lord, cited by Ligon Duncan:
:Theology exists in order to be applied to the day-to-day problems of the Christian church. Every doctrine has its application. All scripture is profitable and all the doctrine is profitable. Similarly all the application must be based on doctrine. In both the Philippians example-passage and the Corinthian example-passage, Paul is dealing with what are surely comparative trivia, the problem of vain glory in a Christian congregation and the problem of failure of Christian liberality. As a Pastor one meets with these difficulties daily. They are standing problems. Yet Paul, as he wrestles with both of them, has recourse to the most massive theology. It’s not only that you have the emphasis on the unity between theology and practice but you have the emphasis on the applicability of the profoundest theology to the most mundane and most common-place problems. Who would ever imagine that the response to the glory of the incarnation might be to give to the collection for the poor? Who might imagine that the application of the glories of New Testament Christology might be to stop our quarreling and our divisiveness in the Christian ekklesia? That is what Paul is doing here. He is telling them: You have these practical problems; the answer is theological; remember your theology and place your behavior in the light of that theology. Place your little problems in the light of the most massive theology. We ourselves in our Christian callings are to be conscious of this. We must never leave our doctrine hanging in the air, nor hesitate to enforce the most elementary Christian obligations with the most sublime doctrines. [emphasis from ahavafriend]
Hypocrit
"...On average, according to these data, women in McCain’s office make $1.04 for every dollar a man makes. In fact, all other things being equal, a typical female staffer could earn 21 cents more per dollar paid to her male counterpart - while adding $10,726 to her annual income - by leaving Obama’s office and going to work for McCain...."
Fairness in Interviewing
Global Warming Justifies Breaking the Law
"The threat of global warming is so great that campaigners were justified in causing more than £35,000 worth of damage to a coal-fired power station, a jury decided yesterday. In a verdict that will have shocked ministers and energy companies the jury at Maidstone Crown Court cleared six Greenpeace activists of criminal damage.
Jurors accepted defence arguments that the six had a "lawful excuse" to damage property at Kingsnorth power station in Kent to prevent even greater damage caused by climate change. The defence of "lawful excuse" under the Criminal Damage Act 1971 allows damage to be caused to property to prevent even greater damage – such as breaking down the door of a burning house to tackle a fire.
The not-guilty verdict, delivered after two days and greeted with cheers in the courtroom, raises the stakes for the most pressing issue on Britain's green agenda and could encourage further direct action...."
Hurricane Journalism
I wish someone would tell these people "Don't you have the sense God gave a goose? Get inside!" Other than great blooper video footage when a huge wave knocks Geraldo Rivera to his knees or you catch them swearing at the wind [forgetting their mic is hot], is there really something more to this whole charade?
Inactivity and Weight Gain
It may sound counterintuitive, but how do we know that inactivity causes overweight and not the other way around? In other words, isn't it possible that metabolic deregulation could cause both overweight and a reduced activity level? The answer is clearly yes. There are a number of hormones and other factors that influence activity level in animals and humans. For example, the "Zucker fatty" rat, a genetic model of severe leptin resistance, is obese and hypoactive (I wrote about it here). It's actually a remarkable facsimile of the metabolic syndrome. Since leptin resistance typically comes before insulin resistance and predicts the metabolic syndrome, modern humans may be going through a process similar to the Zucker rat.
Back to the paper. Dr. Nicholas Wareham and his group followed 393 healthy white men for 5.6 years. They took baseline measurements of body composition (weight, BMI and waist circumference) and activity level, and then measured the same things after 5.6 years. In a nutshell, here's what they found:
- Sedentary time associates with overweight at any given timepoint. This is consistent with other studies.
- Overweight at the beginning of the study predicted inactivity after 5.6 years.
- Inactivity at the beginning of the study was not associated with overweight at the end.
Liberal Pro-Abortion Feminist DEFENDS Palin
"...The witch-trial hysteria of the past two incendiary weeks unfortunately reveals a disturbing trend in the Democratic Party, which has worsened over the past decade. Democrats are quick to attack the religiosity of Republicans, but Democratic ideology itself seems to have become a secular substitute religion. Since when did Democrats become so judgmental and intolerant? Conservatives are demonized, with the universe polarized into a Manichaean battle of us versus them, good versus evil. Democrats are clinging to pat group opinions as if they were inflexible moral absolutes. The party is in peril if it cannot observe and listen and adapt to changing social circumstances.
Let's take the issue of abortion rights, of which I am a firm supporter. As an atheist and libertarian, I believe that government must stay completely out of the sphere of personal choice. Every individual has an absolute right to control his or her body. (Hence I favor the legalization of drugs, though I do not take them.) Nevertheless, I have criticized the way that abortion became the obsessive idée fixe of the post-1960s women's movement -- leading to feminists' McCarthyite tactics in pitting Anita Hill with her flimsy charges against conservative Clarence Thomas (admittedly not the most qualified candidate possible) during his nomination hearings for the Supreme Court. Similarly, Bill Clinton's support for abortion rights gave him a free pass among leading feminists for his serial exploitation of women -- an abusive pattern that would scream misogyny to any neutral observer.
But the pro-life position, whether or not it is based on religious orthodoxy, is more ethically highly evolved than my own tenet of unconstrained access to abortion on demand. My argument (as in my first book, "Sexual Personae,") has always been that nature has a master plan pushing every species toward procreation and that it is our right and even obligation as rational human beings to defy nature's fascism. Nature herself is a mass murderer, making casual, cruel experiments and condemning 10,000 to die so that one more fit will live and thrive.
Hence I have always frankly admitted that abortion is murder, the extermination of the powerless by the powerful. Liberals for the most part have shrunk from facing the ethical consequences of their embrace of abortion, which results in the annihilation of concrete individuals and not just clumps of insensate tissue. The state in my view has no authority whatever to intervene in the biological processes of any woman's body, which nature has implanted there before birth and hence before that woman's entrance into society and citizenship.
On the other hand, I support the death penalty for atrocious crimes (such as rape-murder or the murder of children). I have never understood the standard Democratic combo of support for abortion and yet opposition to the death penalty. Surely it is the guilty rather than the innocent who deserve execution?
What I am getting at here is that not until the Democratic Party stringently reexamines its own implicit assumptions and rhetorical formulas will it be able to deal effectively with the enduring and now escalating challenge from the pro-life right wing. Because pro-choice Democrats have been arguing from cold expedience, they have thus far been unable to make an effective ethical case for the right to abortion.
The gigantic, instantaneous coast-to-coast rage directed at Sarah Palin when she was identified as pro-life was, I submit, a psychological response by loyal liberals who on some level do not want to open themselves to deep questioning about abortion and its human consequences. I have written about the eerie silence that fell over campus audiences in the early 1990s when I raised this issue on my book tours. At such moments, everyone in the hall seemed to feel the uneasy conscience of feminism. Naomi Wolf later bravely tried to address this same subject but seems to have given up in the face of the resistance she encountered.
If Sarah Palin tries to intrude her conservative Christian values into secular government, then she must be opposed and stopped. But she has every right to express her views and to argue for society's acceptance of the high principle of the sanctity of human life. If McCain wins the White House and then drops dead, a President Palin would have the power to appoint conservative judges to the Supreme Court, but she could not control their rulings.
It is nonsensical and counterproductive for Democrats to imagine that pro-life values can be defeated by maliciously destroying their proponents. And it is equally foolish to expect that feminism must for all time be inextricably wed to the pro-choice agenda. There is plenty of room in modern thought for a pro-life feminism -- one in fact that would have far more appeal to third-world cultures where motherhood is still honored and where the Western model of the hard-driving, self-absorbed career woman is less admired.
But the one fundamental precept that Democrats must stand for is independent thought and speech. When they become baying bloodhounds of rigid dogma, Democrats have committed political suicide.
Stuff White People Like .com
I will link this on the side for future and frequent visiting. I found the guy's writing to be very intelligent and funny. Let me know what you think.
Catholic Politicians and Abortion
Well, the Arch Bishop of the Denver Catholic Church has responded clearly that this is an unacceptable view for Catholics to hold. It's a powerful letter for all Christian believers to read, and respond to.
Sowell on Competing Visions in the '08 Election
"...It is hardly surprising that young people prefer the political left. The only reason for rejecting the left's vision is that the real world in which we live is very different from the world that the left perceives today or envisions for tomorrow.Most of us learn that from experience-- but experience is precisely what the young are lacking.
...
Ordinary working class people did not lead the stampede to Barack Obama, even before his disdain for them slipped out in unguarded moments.
The agenda of the left is fine for the world that they envision as existing today and the world they want to create tomorrow.
That is a world not hemmed in on all sides by inherent constraints and the painful trade-offs that these constraints imply. Theirs is a world where there are attractive, win-win "solutions" in place of those ugly trade-offs in the world that the rest of us live in.
...
Personally, I wish Ronald Reagan could have talked the Soviets into being nicer, instead of having to spend all that money. Only experience makes me skeptical about that "kinder and gentler" approach and the vision behind it."
A Practical Approach to Omega Fats
- Hunter-gatherers living mostly on land animals: 2:1 to 4:1
- Pacific islanders getting most of their fat from coconut and fish: 1:2
- Inuit and other Pacific coast Americans: 1:4 or less
- Dairy-based cultures: 1:1 to 2:1
- Cultures eating fish and grains: 1:2 or less
I think there's a simple way to interpret all this. Number one, don't eat vegetable oils high in n-6 fats. They are mostly industrial creations that have never supported human health. Number two, find a source of n-3 fats that can approximately balance your n-6 intake. In practical terms, this means minimizing sources of n-6 and eating modest amounts of n-3 to balance it. Some foods are naturally balanced, such as grass-fed dairy and pastured lamb. Others, like coconut oil, have so little n-6 it doesn't take much n-3 to create a proper balance.
Animal sources of n-3 are the best because they provide pre-formed long-chain fats like DHA, which some people have difficulty producing themselves. Flax oil may have some benefits as well. Fish oil and cod liver oil can be a convenient source of n-3; take them in doses of one teaspoon or less. As usual, whole foods are probably better than isolated oils. Weston Price noted that cultures throughout the world went to great lengths to obtain fresh and dried marine foods. Choose shellfish and wild fish that are low on the food chain so they aren't excessively polluted.
I don't think adding gobs of fish oil on top of the standard American diet to correct a poor n-6:n-3 ratio is optimal. It may be better than no fish oil, but it's probably not the best approach. I just read a study, hot off the presses, that examines this very issue in young pigs. Pigs are similar to humans in many ways, including aspects of their fat metabolism. They were fed three diets: a "deficient" diet containing some n-6 but very little n-3; a "contemporary" diet containing a lot of n-6 and some n-3; an "evolutionary" diet containing a modest, balanced amount of n-6 and n-3; and a "supplemented" diet, which is the contemporary diet plus DHA and arachidonic acid (AA).
Using the evolutionary diet as a benchmark, none of the other diets were able to achieve the same fatty acid profile in the young pigs' brains, blood, liver or heart. They also showed that neurons in culture require DHA for proper development, and excess n-6 interferes with the process.
With that said, here are a few graphs of the proportion of n-6 in common foods. These numbers all come from nutrition data. They reflect the percentage n-6 out of the total fat content. First, animal fats:
Except salmon oil, these are traditional fats suitable for cooking. Except schmaltz (chicken fat), they are relatively low in n-6. Next, vegetable oils:
These range from very low in n-6 to very high. Most of the modern, industrially processed oils are on the right, while most traditional oils are on the left. I don't recommend using anything to the right of olive oil on a regular basis. "HO" sunflower oil is high-oleic, which means it has been bred for a high monounsaturated fat content at the expense of n-6. Here are the meats and eggs:
n-3 eggs are from hens fed flax or seaweed, while the other bar refers to conventional eggs.
A few of these foods are good sources of n-3. At the top of the list is fish oil, followed by n-3 eggs, grass-fed butter, and the fat of grass-fed ruminants. It is possible to keep a good balance without seafood, it just requires keeping n-6 fats to an absolute minimum. It's also possible to overdo n-3 fats. The traditional Inuit, despite their good overall health, did not clot well. They commonly developed nosebleeds that would last for three days, for example. This is thought to be due to the effect of n-3 on blood clotting. But keep in mind that their n-3 intake was so high it would be difficult to achieve today without drinking wine glasses full of fish oil.
Launching a New School
The Church and Evangelism
food sept. 6-7
Omega Fats and Cardiovascular Disease
One of the interesting things about the modern Inuit diet is it's most often a combination of Western and traditional foods. For example, they typically use white flour and sugar, but continue to eat seal oil and fish. Both seal oil and fish are a concentrated source of long-chain omega-3 (n-3) fatty acids.The 'paradox' makes much more sense to me now that I've seen this:
It's from the same paper as the graphs in the last post. Note that it doesn't take much n-3 to get you to the asymptote. Here's another one that might interest you:
The finding in this graph is supported by the Lyon diet heart study, which I'll describe below. One more graph from a presentation by Dr. Lands, since I began by talking about the Inuit:
Cardiovascular disease mortality tracks well with the n-6 content of blood plasma, both across populations and within them. You can see modern Quebec Inuit have the same low rate of CVD mortality as the Japanese. The five red triangles are from MRFIT, a large American intervention trial. They represent the study participants divided into five groups based on their plasma n-6. Note that the average percentage of n-6 fatty acids is very high, even though the trial occurred in the 1970s! Since n-3 and n-6 fats compete for space in human tissue, it makes sense that the Inuit are protected from CVD by their high n-3 intake. [Update: I don't read too much into this graph because there are so may confounding variables. It's an interesting observation, but take it with a grain of salt.. SJG 2011].
Now for a little mechanism. Dr. Lands' hypothesis is that a high n-6 intake promotes a general state of inflammation in the body. The term 'inflammation' refers to the chronic activation of the innate immune system. The reason is that n-3 and n-6 fats are precursors to longer-chain signaling molecules called eicosanoids. In a nutshell, eicosanoids produced from n-6 fatty acids are more inflammatory and promote thrombosis (clotting) more than those produced from n-3 fatty acids. Dr. Lands is in a position to know this, since he was one of the main researchers involved in discovering these mechanisms. He points out that taking aspirin to 'thin' the blood and reduce inflammation (by inhibiting inflammatory eicosanoids) basically puts a band-aid over the problem caused by excess n-6 fats to begin with. [Update- this mechanism turns out not to be so straightforward. SJG 2011]
The Lyon Diet Heart Study assessed the effect of n-3 fat supplementation on CVD risk. The four-year intervention involved a number of diet changes designed to mimic the American Heart Association's concept of a "Mediterranean diet". The participants were counseled to eat a special margarine that was high in n-3 from alpha-linolenic acid. Overall PUFA intake decreased, mostly due to n-6 reduction, and n-3 intake increased relative to controls. The intervention caused a 70% reduction in cardiac mortality and a large reduction in all-cause mortality, a smashing success by any measure.
In a large five-year intervention trial in Japan, JELIS, patients who took EPA (a long-chain n-3 fatty acid) plus statins had 19% fewer cardiac events than patients taking statins alone. I don't know why you would give EPA by itself when it occurs with DHA and alpha-linolenic acid in nature, but it did nevertheless have a significant effect. Keep in mind that this trial was in Japan, where they already have a much better n-6/n-3 ratio than in Western nations.
In my opinion, what all the data (including a lot that I haven't included) point to is that a good n-6 to n-3 ratio may be important for vibrant health and proper development. In the next post, I'll talk about practical considerations for achieving a good ratio.
food sep. 5
Omega-3 Fats and Brain Development
The bottom line is short and sweet: compared to the children of mothers who ate 340 grams or more of fish per week, children whose mothers ate very little fish had an increased risk of low verbal intelligence, poor social behavior, poor motor skills, poor communication skills, and poor social development. These associations remained after adjusting for 28 potential confounders, including social status, level of education, stressful life events, smoking, alcohol, and several others.
In support of this association, in another study the four-year-old children of mothers who were given DHA and arachidonic acid supplements had higher IQs than those given "placebo" (corn oil). There have been a number of trials of varying quality that have shown varying results with n-3 supplementation, so I'll leave you to decide what you think of this. A 2007 review I found on n-3 supplementation and brain development states that "the evidence for potential benefits of LCPUFA [long-chain polyunsaturated fatty acid] supplementation is promising but yet inconclusive".
I do think it's interesting to note that the brain has the highest concentration of long-chain n-3 fats of any organ, and eating n-3 fats in the form of fish, fish oil or cod liver oil increases the amount in tissues. Eating too much n-6 depletes the brain of DHA and adversely affects neuron development in piglets. n-3 deficiency affects the release of serotonin (a neurotransmitter) in rat brains.
Put it all together, including the data from the last two posts, and I think there's some evidence that a good balance of n-3 to n-6 fatty acids is important for optimal brain function and perhaps development.
corn and zucchini salad
food sept. 3 and 4
Palin Acceptance Speech!
7:36 p.m.: How uncomfortable is that boyfriend? He should be at his senior prom, not on display at the RNC.
7:37 p.m.: Mother of a military man. Mother of a special needs child? What’s next? Mother of a pregnant teenager? Hold on.
As for my thoughts, I actually stayed up so I could watch the speech again when they replayed it. I loved the whole thing. Her humor and wit are priceless. I think I have a crush! There were so many great one-liners. Wow! Can't wait for the VP debates.
Palin on Energy
Experience
"...Buchanan was the most qualified person to run for president, before or since.The article goes on to suggest that Palin is possibly the fusion of the needed traits, which will help Washington in this time. I am excited to see if this is true. I have an inkling it is.At least he was if varied experience in high offices fully defines who is "qualified." But it does not.
Buchanan had been a five-term congressman, then ambassador to Russia, then a two-term senator, then secretary of state, then ambassador to Britain. Buchanan then became perhaps the worst president.
Clearly, experience is not sufficient to prove a person "qualified" for the presidency. But it is a necessary component of qualification.
So are two other attributes. One is character. Richard Nixon was qualified by his experience as congressman, senator and vice president, but disqualified by character. The second is a braided mental rope of constitutional sense and political common sense."
UPDATE: Here is another great article, this one by Thomas Sowell regarding "Foreign Policy Experience."
Sept. 2 food
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September
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- Acne: Disease of Civilization
- nachos
- Collard green smoothie
- sept. 28-29 food
- The Meaning of Mission
- Ratatouille
- sept. 27 food
- sept. 26 food
- Nonalcoholic Fatty Liver Disease
- sept 25, 2008 food
- daal with quinoa and peas
- blueberry fig sorbet
- what this blog is about
- sept 23-24 food
- Agave Syrup
- How to Fatten Your Liver
- "Spaghetti"
- food sept 21-22
- food Sept. 20, 08
- back from my trip
- A New Toy
- The Assemblies of God
- 10 Rules of Political Bluffing
- Theology in Real Life
- Hypocrit
- Fairness in Interviewing
- Global Warming Justifies Breaking the Law
- Hurricane Journalism
- Inactivity and Weight Gain
- Liberal Pro-Abortion Feminist DEFENDS Palin
- Stuff White People Like .com
- Catholic Politicians and Abortion
- Sowell on Competing Visions in the '08 Election
- Lipstick
- A Practical Approach to Omega Fats
- Launching a New School
- The Church and Evangelism
- food sept. 6-7
- Omega Fats and Cardiovascular Disease
- food sep. 5
- Omega-3 Fats and Brain Development
- corn and zucchini salad
- food sept. 3 and 4
- Palin Acceptance Speech!
- Palin on Energy
- Experience
- Sept. 2 food
- The Omega Ratio
- Vegetable Oil and Homicide
- Okra salad
- food aug 31 and sept 1
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September
(51)